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Dutsadee Suttho1, 2
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DOI:10.17265/1548-6648/2022.02.003
1. Nuclear medicine department, Maharat Nakhon Ratchasima Hospital, Ministry of Public Health, Thailand
2. The Faculty of Allied Health Sciences, Thammasat University, Rangsit Campus, Pathum Thani, Thailand
To ensure the radiation safety for public, caregiver and family members from the patients who need high dose radioactive iodine treatment. The patients require isolation in a lead shielded room for certain period of time and released them if the radioactivity remaining in the body less than 1.2 GBq. The aim of this study was to estimate the isolation time and investigate the possibility of earlier release from hospitalization. This study was retrospective analysis of data from 136 patients who required hospitalization to treat thyroid cancer with I-131. The radiation dose rates were measured by using a radiation detector at 1.0 m from the anterior neck of patient immediately after I-131 administration and subsequent at 24, 48, 72 and 96 h respectively. The measured data were plotted using a Microsoft Excel; the effective half-life (Teff) was derived using a curve fit function of the spreadsheet program assuming. The mean Teff to all patients obtained by excel were 17.33 and 34.65 h for the initial fast and the second slower clearance phase, respectively. The dose rate from patient decreased in a bi-exponential pattern, where there is a fast clearance of radioiodine in the first day post I-131 treatment and a slower clearance after this time. The isolation time depends on the Teff value instead of the administered I-131 activity and this study has demonstrated that after 24 h post I-131 radiation dose rate at 1 m was less than 70 µSv/h. Based on dose rate measurement to release the patients, this suggests that a majority of the patients could be discharged from the isolation room after 24 h after I-131 treatment.
Radioiodine treatment, thyroid cancer, isolation time
Journal of US-China Medical Science 19 (2022) 67-69
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