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Formulation, in-vitro Evaluation and Dissolution Enhancement of Griseofulvin by Solid Dispersion Method



Author(s)

Gopal Pokhrel, Bikash Dani, Srijana Shrestha, Rakshya Chaudhary, Ramesh Dhami, Barnabas Sunuwar, Sharad Pudasaini, Vijay Yadav, Lalit Mohan Pant and Rajan Ghimire

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DOI:10.17265/2328-2150/2022.04.003

Introduction: Griseofulvin is an antifungal drug belonging to Biopharmaceutical Classification System (BCS class II) having low solubility. Objectives: To formulate, evaluate and enhance the dissolution of poorly water soluble drug Griseofulvin by using solid dispersion method. Methods: Six formulations were prepared by solid dispersion method using Polyethylene Glycol (PEG 6000) 125 mg, 0 mg, 62.5 mg, 100 mg, 25 mg, 150 mg and superdisintegrants Crospovidone 0 mg, 125 mg, 62.5 mg, 100 mg, 25 mg, 150 mg in all batches respectively. Findings: Satisfactory results were obtained from evaluation of physical characteristics of Griseofulvin tablets including: carr’s compressibility index (17.5 ± 0.19% to 11.76 ± 0.67%), Hausner ratio (1.21 ± 0.01 to 1.13 ± 0.02) and post compression parameters including: thickness (5.16 ± 0.02 mm to 4.57 ± 0.19 mm), friability (0.024% to 0.322%), hardness (4 ± 0.28 kg/cm² to 5 ± 0.57 kg/cm²), disintegration time (14-870 seconds). Conclusions: F3 was best formulation among all formulated batches with in-vitro drug release 30.05% in 10 minutes, 69.21% in 30 minutes and 97.11% in 45 minutes. This indicated that formulation F3 batch with PEG 6000 of 62.5 mg and crospovidone 62.5 mg showed increased dissolution.

Griseofulvin, formulation, solid dispersion, solubility, evaluation.

Pokhrel, G., Dani, B., Shrestha, S., et al. 2022. "Formulation, in-vitro Evaluation and Dissolution Enhancement of Griseofulvin by Solid Dispersion Method." Journal of Pharmacy and Pharmacology 10 (4): 125-131.