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The Clinical Use of Mediator Release Test in Food Sensitivities



Author(s)

Daria M. Adamczak^{1, 2}

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DOI:10.17265/2159-5828/2018.01.007

1. Private Clinic Derma Solutions, Szczepankowo 94A, Poznan 61-306, Poland
2. Poznan University of Medical Sciences, Coll. Maius, Fredry 10, Poznan 61-701, Poland

Food sensitivities are non-IgE-mediated, non-coeliac, dose-dependent and delayed systemic responses to food. They consist of a highly complex class of adverse food reactions; however, their last phase is the release of mediators from leukocytes. The Mediator Release Test (MRT) is a functional measure of sensitivity-based inflammatory responses. It is an end-point test, which can account for the widest range of triggering mechanisms involved in sensitivity reactions, including both innate and adaptive pathways. MRT not only tests reactions to foods, food-chemicals, and other substances, but also reliably quantifies the degree of the inflammatory response. The test opens the new therapeutic options for food sensitivities.

MRT, adverse food reactions, food sensitivity.