Epidemiology of Helicobacter pylori Infection and Related Gastric Pathologies in Moroccan Population
Author(s)
Ghizlane Bounder1,2, Hasna Boura1, SalouaNadifiyine1, Mohamed Reda Jouimyi1,2, Mariem Bensassi1, Maria Kadi4, Meriem Eljihad4, Wafa Badre4, Hakima Benomar3, Anass Kettani2, Halima Lebrazi2 and Fatima Maachi1
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DOI:10.17265/1934-7391/2017.05.001
Affiliation(s)
1. Laboratory of Helicobacter Pylori and Gastric Pathologies, Institut Pasteur du Maroc, Casablanca 20360, Morocco
2. Laboratory of Biology and Health. Faculty of Sciences Ben M’sik, University Hassan II, Casablanca 20800, Morocco
3. Laboratory of Histo-Cytopathology, Institut Pasteur du Maroc, Casablanca 20360, Morocco
4. Gastroenterology Department, Ibn Rochd University Hospital Center, Casablanca 20360, Morocco
ABSTRACT
Helicobacter pylori (H. pylori) colonize the gastric mucosa
of 50% of the world’s population. This infection is closely associated with the
development of peptic ulcer disease and gastric cancer. The present study was conducted
to assess the prevalence of H. pylori infection in Moroccan population
and the risk to develop gastric precancerous lesions and gastric cancer. Totally,
298 patients were enrolled, 68 of asymptomatic subjects and 230 of patients with
gastric diseases. Histological examination was effected to diagnostic gastric lesions
and to detect H. pylori. ELISA was used
to determine H. pylori status of patients. The prevalence of H. pylori within asymptomatic and symptomatic
subjects was observed higher. A significant relationship
was detected between H. pylori infection
and the risk of gastric diseases (p-value < 0.0001). A meaningful
association between chronic gastritis increasing and age was observed (p-value = 0.03). The risk to develop gastric
cancer among infected patients was observed elevated with rate of 9%. Our results
showed a high prevalence of H. pylori in both asymptomatic and
gastric diseases patients. We noticed that chronic gastric infection increases with
age. We remarked also that the risk to develop gastric cancer among infected patients
was elevated in our population.
KEYWORDS
Helicobacter pylori, prevalence, Moroccan population, gastric diseases, gastric cancer.
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