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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Article
Author(s)
Nguyen Van Hue1, 2, Nguyen Van Toan2, Le Thanh Long2, Guido Fleischer1 and Zhou Guang Hong1
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DOI:10.17265/2161-6256/2015.12.004
Affiliation(s)
1. Key Laboratory of Meat Processing and Quality Control (MOE), National Center of Meat Quality and Safety Control (MOST), College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
2. College of Agriculture and Forestry, Hue University, 102 Phung Hung Street, Hue City 47000, Vietnam
ABSTRACT
The
paper aimed to study the toxic
effects of the degradation products of oxytetracycline and chlortetracycline,
such as, α-apo-oxytetracycline (α-apo-OTC), β-apo-oxytetracycline (β-apo-OTC),
anhydro-chlortetracycline (ACTC) and 4epi-anhydro-chlortetracycline (EACTC) on
rats. Male rats received oral doses of 10 mg/kg body weight/day of either
α-apo-OTC, β-apo-OTC, ACTC or EACTC for 90 d. At the end of 90 d treatment, the body/organ weight, white blood cell count (WBC), red blood cell count
(RBC), hemoglobin (HGB), hematocrit (HCT), platelet (PLT) count, blood urea
nitrogen (BUN), serum glutamic oxaloacetic transaminase (SGOT) and serum
glutamic pyruvic transaminase (SGPT) were measured. The results revealed that the rats treated with α-apo-OTC or ACTC for 90 d did not affect body,
organ
weights or certain blood- and serum-factors, however, those treated with
β-apo-OTC or EACTC exhibited significant decreases in body weights, RBC counts
and HGB concentrations, as well as significant increases in BUN concentrations,
SGOT and SGPT activities. The results of this study suggested
that the toxic effects of β-apo-OTC or EACTC treatment could damage liver and
kidney tissues of rats, as well as lead to the degeneration and necrosis in the
hepatocytes.
KEYWORDS
Antibiotic, oxytetracycline and chlortetracycline degradation products, toxic effects, rats.
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