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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Article
Author(s)
Patricia Alves de Almeida, Janaína Nones, Andrea Gonçalves Trentin and Jader Nones
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DOI:10.17265/2328-2150/2015.05.005
Affiliation(s)
ABSTRACT
Flavonoids are phenolic compounds with biological and pharmacological properties, such as antioxidant and antiviral effects. In the present work, we evaluated the effect of the flavonoids quercetin and rutin in human SD-MSCs (skin derived-multipotent mesenchymal stromal cells). Cultured SD-MSCs were exposed to different concentrations of flavonoids (80 to 320 μM) for 2 days in vitro. Cell viability was assessed by MTT assay and cell proliferation by BrdU staining. Cell death was quantified by the analysis of picnotic nuclei. In this paper, we demonstrated for the first time that both quercetin and rutin affect the viability of SD-MSCs, although high concentrations of quercetin (320 μM) promoted increased values of picnoctic nuclei. Quercetin treatment increased cell proliferation and, in contrast, rutin in the same concentration decreased these values. Our results may aid the comprehension of flavonoids effect in SD-MSCs. However, a better understanding of the mechanisms involving flavonoids and SD-MSCs interactions are necessary.
KEYWORDS
Bioactive substances, cell survival, cytotoxicity, flavonoids, human mesenchymal stromal cells.
Cite this paper
de Almeida, P. A., et al. 2015. “Quercetin and Rutin Affect the Survival and Proliferation of Human Skin-Derived Multipotent Mesenchymal Stromal Cells.” Journal of Pharmacy and Pharmacology 3 (5): 237-242.
References