Affiliation(s)
1. Institute of Macromolecules, Federal University of Rio de Janeiro, Rio de Janeiro 21941-598, Brazil
2. Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro 21941-599, Brazil
3. Program of Materials Engineering and Metallurgy, Technology Center, Alberto Luiz Institute of Coimbra, Post-Graduation and Engineering Research - COPPE, Federal University of Rio de Janeiro, Rio de Janeiro 21941-594, Brazil
ABSTRACT
Cashew gum is a branched chain
heteropolysaccharide extracted from the cashew tree (Anacardium occidentale L.). Purified cashew gum (PCG) is free of
plant contaminants and is highly soluble. Several studies have indicated this
polymer can be relevant in the pharmaceutical industry for production of
tablets. Recently, our research group reported that PCG can be used as a
diluent for tablets produced by direct compression. Nystatin (Nys) is the drug
of first choice for treatment of oral candidiasis, in the form of a suspension.
The treatment consists of up to six daily doses of a suspension of nys at
500,000 IU, causing low therapeutic adhesion by patients. The objective of this
study was to investigate the behavior of PCG together with nys and other
excipients (flavoring agents and lubricating agent) for future manufacture of
mucoadhesive buccal tablets by direct compression. For that purpose, we
performed pre-formulation tests (FTIR, TGA, XRD, solubility, pH, granulometry,
swelling degree and powder flow) with physical mixtures of the drug and
excipients. The results were excellent, demonstrating that PCG is a polymer
with potential for this type of application.
KEYWORDS
Purified cashew gum, nystatin,
mucoadhesive buccal tablets.
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