Contact us
[email protected] | |
3275638434 | |
Paper Publishing WeChat |
Useful Links
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Article
The Theory of Dove-like Particles
Author(s)
SUN Zuodong
Full-Text PDF XML 1831 Views
DOI:10.17265/1548-6648/2019.02.004
Affiliation(s)
Ya’ou Brain Science Institute of Heilongjiang Province, Harbin 150090, China
ABSTRACT
Objective: Alzheimer’s disease (AD) has
been reported for more than 100 years since its first discovery in 1906. There has
been no significant progress in the study of its real causes and pathogenesis.
The viewpoint of this paper is a heuristic viewpoint based on brain cell
activation theory under such background. In this paper, the pathogenesis of
sporadic AD is discussed at molecular level by applying the principles of cell
physics and biology. The purpose of this paper is to harmonize the existing
theories of etiology of AD and to solve the source problems that have plagued
the research field of neurodegenerative diseases for a long time. Method: (1) Discuss the
relationship with the existing hypothesis: the Aβ protein hypothesis, the tau
protein hypothesis, the presenilin (PS) hypothesis, the apolipoprotein E (ApoE)
hypothesis, the cholinergic hypothesis, the inflammatory hypothesis; (2) Demonstration:
biophysical proof, medical pathological proof, biological model proof; (3) Interpretation: ion
channel and blood-brain barrier, potassium ion and potassium channel, ion pump
and epilepsy and cancer, A beta protein and spots and plaques, related AD
solutions. Result: (1) Abeta is not the cause of AD, but the remains of brain cells after abnormal
apoptosis; (2) The K+ concentration difference of 0.00001% which causes the great change of membrane
potential is the effective concentration, which can not be neglected; (3) Abnormal
impairment of potassium channels and early entry of sodium ions to occupy
potassium positions are related to epilepsy, cancer and HeLa cells; (4) AD is a physical disease, especially transcranial magnetoelectricity
stimulation, should be the first choice for treatment,
which can activate abnormal neurons accurately without
interfering with normal neurons. Conclusion: (1)
Basic contents: excess cations are transferred from
extracellular to intracellular. They compete position with potassium ions on
the inner surface of cell membranes, thus abatementing the membrane potential,
making action potential unable to activate calcium channels normally, which
eventually leads to abnormal apoptosis of brain cells. Amyloid plaque is the remains of abnormal
apoptotic brain cells. Amyloid plaque is the aggregation of amyloid spots by
van der Waals force and electrostatic attraction, and its interstitium is
amyloid protein. Brain
cells consist of neurons, microglia and astrocytes in turn. Most of the spotted
nuclei in the remains are cations. (2) Solutions: the core viewpoint of this paper can be
regarded as exploring the etiology of sporadic AD, it is companion volume of
Brain cell activation theory, brain cell activation theory is an explanation of the
treatment methods and mechanism of neurodegenerative diseases such as AD, it is
suitable for encephalopathy but not limited to encephalopathy, the solution of
AD should start with prevention and treatment, the external factor of
prevention is environment, especially heavy metal ions, the internal cause is
body acidity and alkalinity, physical means, especially transcranial
magnetoelectricity stimulation, should be the first choice for treatment. (3) Naming principles:
because of the core point of view in this paper—The position of cation
occupying potassium is the initiating factor of AD, so the etiology theory is
named theory of dove-like
particles. Take the Chinese idiom “Turtledove occupies the nest of magpies”. “Turtledove” represents the
non-essential cation, “magpie” refers to the effective potassium ion, and “nest” refers to the
position of the effective potassium ion.
KEYWORDS
Alzheimer, etiology, cationic placement, amyloid plaque, cell remains, physical mean.
Cite this paper
References