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Article
Author(s)
Agatha Magistalia Cahiadewi1, Yanuar Iman Santosa2, Anna Mailasari Kumala Dewi2 and Suprihati2
Full-Text PDF XML 408 Views
DOI:10.17265/2328-7136/2019.01.004
Affiliation(s)
1. Faculty of Medicine.Diponegoro University, Semarang 50236, Indonesia
2. Ear Nose and Throat Department, Faculty of Medicine, Diponegoro University, Semarang 50236, Indonesia
ABSTRACT
Background: United airway
disease, a comorbid of allergic rhinitis and asthma, leads to the accumulation
of toxic eosinophil in the lung parenchyma as a result of allergic reaction.
Ovalbumin (OVA) sets off a condition of eosinophilia in the respiratory tract.
Zinc supplementations
are proposed to decrease the amount of eosinophil in the lung parenchyma due to
its cytoprotective, anti-inflammation and antioxidant activity. Objectives: Proving
the effects of the zinc supplementation on the number of eosinophil in the lung
histopathology preparations of the BALB/c mice that were sensitized with OVA. Method: A post-test only
control group design was used, which
consisted of eighteen female BALB/c mice divided into three groups: the
negative control group (K1), positive control group with OVA sensitization
(K2), and group of mice with OVA sensitization and 5
mg/kg body weight zinc supplementation (P). The
treatments were given for 30 days and then eosinophils in the lung histopathology
preparations of the BALB/c mice were counted.
Results: The mean eosinophil count in the negative
control group (K1) was 0.48, the positive control group (K2) was 2.12, and the
group of mice with OVA sensitization and 5
mg/kg body weight zinc supplementation (P) was 0.76. The
number of eosinophil in the lungs in the K2 group was significantly higher than
the K1 group (p = 0.000) and the P group was
significantly lower than K2 group in ANOVA Test followed by Post Hoc Test (p = 0.001).
Conclusion: The zinc supplementation reduces the
number of eosinophil in the lungs tissue of the BALB/c mice that were
sensitized with OVA.
KEYWORDS
Zinc, ovalbumin, eosinophil, allergic rhinitis, asthma.
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