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Comparison of the Analgesic Effect of Low-Intensive Polarized Polychromatic Light and Analgesics



Author(s)

Sergiy A. Gulyar1, 2 and Zynaida A. Tamarova1

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DOI:10.17265/1548-6648/2019.01.001

On the model of formalin test in mice, the analgesic effects of low-intensity polarized light (PL) of BIOPTRON device (480-3,400 nm, polarization up to 95%, power density 40 mW/cm2) and three pharmacological analgesics (ibuprofen, analgin, tramal) were compared. We used analgesics in the optimal and half-dose, as well as half-doses of analgesics combined with the application of PL to the analgesic acupuncture point (AP) E-36. Pain was induced by subcutaneous injection of a 5% formalin solution (30 μL) into the back of the foot of the left hind limb of the animal. The intensity of pain was judged by duration of pain (licking of the affected limb) and non-painful (sleeping, eating, running, washing) behavioral reactions during 60 minutes of observation. In animals that immediately after the creation of the locus of tonic pain, received an injection (intraperitoneally) of ibuprofen, analgin or tramal in optimal doses (30.0; 8.3 and 1.7 mg/kg), duration of the pain response reduced by 46.0; 74.9 and 56.2%, respectively. Half doses of these analgesics (15.0; 4.2 and 0.8 mg/kg) weakened the pain by 23.1; 28.5 and 34.2%. A statistically significant reduction of pain was also observed in groups where instead of analgesics, was applied a 10-min PL session to the anti-pain AP E-36 (by 27.0%) or to the locus of pain (by 35.8%). These data indicate that PL analgesic effect is comparable to the effect of moderate doses of analgesics. Combined use of analgesic and PL suppresses pain more effectively than one analgesic in the same dose. The 10-minute PL application to the analgesic AP E-36 in 1.5-2 times (statistically significantly) increased the analgesic effect of small analgesics doses. In contrast to animals in which analgesia was caused by administration of high doses of analgesics, in the case of low doses of analgesic in combination with PL, caused no disturbances in motor activity and eating behavior. Clinical significance of the presented data is to prove the possibility of reducing the dose of analgesic pharmaceuticals by applying PL, which reduces the risk of unwanted side post-pharmacological effects.

Polarized light, bioptron device, pain, formalin test, analgesia, ibuprofen, analgin, tramal, acupuncture point.