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Article
Author(s)
Yimin Wang1 and Tao Zhao1, 2
Full-Text PDF XML 411 Views
DOI:10.17265/2328-7136/2018.06.004
Affiliation(s)
1. Research & Development Center, Shandong Buchang Pharmaceutical Company Limited, Heze, Shandong Province 274000, China
2. Institute of Panvascular Medicine, Fudan University, Shanghai 200032, China
ABSTRACT
Objective:
To investigate the effects of Naoxintong (NXT) capsule on vascular endothelial
function and inflammatory mechanism in spontaneously hypertensive rats.
Methods: A total of 100 spontaneously hypertensive rats were divided into model
group, positive control group, NXT low-dose group, NXT medium-dose group and
NXT high-dose group. Rats in the model group were given an equal dose of normal
saline once a day; the positive control group was given telmisartan 50 mg/(kg·d)
once a day; the low, middle and high dose groups were given the NTX 0.5, 1.0,
2.0 mg/(kg·d) once a day, respectively. Rats in each group were continuously
intragastrically administered for 12 weeks. The vascular endothelial function
index, inflammation index and blood pressure of each group were observed at the
end of 8 weeks. Results: Endothelin (ET), interleukin-6 (IL-6), tumor necrosis
factor-α (TNF-α), C-reactive protein (CRP) and systolic blood pressure levels
were lower in the positive control group and NXT group compared with model
group. In the model group, the NO level was lower than the positive control
group and NXT group; the levels of ET, IL-6, TNF-α, CRP and systolic blood
pressure in the middle-dose group and the high-dose group were lower than those
in the positive control group and NXT low-dose group. Furthermore, the level of
NO was higher in positive control group and NXT middle and high dose group
compared with model group. The levels of ET, IL-6, TNF-α, CRP and systolic
pressure in NXT high dose group were lower than in NXT middle dose group, while
the level of NO was higher in NXT high group than in NXT middle dose group and
the difference was statistically significant (p < 0.05). Conclusions: NXT has obviously antihypertensive
effect on spontaneously hypertensive rats, and its mechanism may be related to
the improvement of vascular endothelial function and inflammatory factors.
KEYWORDS
Naoxintong capsule, spontaneous hypertension, vascular endothelial function, inflammatory factor.
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