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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Article
Author(s)
Claudio Frezza1, Alessandro Venditti2, Cecilia Scandurra2, Alessandro Ciccòla2, Ilaria Serafini2, Fabio Sciubba2, Sebastiano Foddai1, Marco Franceschin2, Armandodoriano Bianco2 and Mauro Serafini1
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DOI:10.17265/2161-6256/2018.03.004
Affiliation(s)
1. Dipartimento di Biologia Ambientale,Università di Roma “La Sapienza”, Piazzale Aldo Moro 5, Rome 00185, Italy
2. Dipartimento di Chimica,Università di Roma “La Sapienza”, Piazzale Aldo Moro 5, Rome 00185, Italy
ABSTRACT
In this work, the half-matured female cones of the rare species, Wollemia nobilis, were studied for their
phytochemical profile for the first time. Fourteen compounds were isolated and
identified by means of column chromatography, Nuclear Magnetic Resonance (NMR) spectroscopy and Mass Spectrometry (MS). In particular,
these compounds were acetyl-isocupressic acid (1), methyl-(E)-communate
(2), sandaracopimaric acid (3), wollemol (4), 7''-O-methyl-agathisflavone
(5), 7,4'''-di-O-methyl-agathisflavone (6), shikimic acid (7), quinic acid (8), glucose (9),
sucrose (10), raffinose (11), D-lactic acid (12), succinic acid (13)
and alanine (14). The chemotaxonomic
implications of their presence were discussed and a preliminary phytochemical
comparison between these cones and the male ones was also performed. This
evidenced several similarities but also some differences that were widely
treated about. Moreover, a preliminary nutraceutical evaluation of these cones,
based on phytochemistry, was carried out. Actually, this showed a good
nutraceutical potentiality of the half-matured cones but also some potential critical
state mainly due to the occurrence of acetyl-isocupressic acid (1), which is quite known
to have some adverse pharmacological effects. For this reason, more in-depth
nutraceutical studies would be necessary to exactly determine the ethnopharmacological
and nutraceutical value of these cones.
KEYWORDS
Wollemia nobilis, half-matured female cones, phytochemical analysis, primary and secondary metabolites, chemotaxonomy, ethnopharmacology, nutraceutics.
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