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Effect of Gold Nanocomposite on the Cytotoxicity of Human Cancer Cell Lines



Author(s)

A. M. H. Abaza, G. A. Mahmoud and B. B. Elsheikh

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DOI:10.17265/2328-2150/2018.08.003

Gold nanoparticles (AuNPs) have a biological property that have attracted significant attention in this decade, especially in the field of biomedical application with great therapeutic potential. Additionally, the chitosan molecule appears to be a suitable polymeric complex used in this field. The aim of the current study is to explores the cytotoxicity and the IC₅₀ value of Au-doped chitosan-poly (vinyl alcohol) (Cs/PVA/Au) nanocomposite that was developed by gamma irradiation with promising anticancer activity. The anti-cancer activity of the prepared nanocomposites was demonstrated in human liver cancer cell line HEPG2 and MCF7 breast cancer cell lines. It has significant effects against both cancer cell line. Concluding that, the future nanomedicine will be impacted greatly by the collaboration of biomedical research and developing nanoparticle therapy in the right directions, which will improve the outcome of cancer patients. It is expected that the next decade will reveal real potential for metal nanoparticles to cross the regulatory barrier into clinical use as effective therapeutics.

Chitosan nanocomposite, gold nanoparticles, liver and breast cell line.

Abaza, A. M. H., Mahmoud, G. A., and Elsheikh, B. B. 2018. “Effect of Gold Nanocomposite on the Cytotoxicity of Human Cancer Cell Lines.” Journal of Pharmacy and Pharmacology 6 (8): 729-741.