[email protected] | |
3275638434 | |
Paper Publishing WeChat |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
How Spines Cross-Talk: Compartmental Model of Heterosynaptic Plasticity
Zhang Zhong and Li Yinyun
Full-Text PDF XML 503 Views
DOI:10.17265/2328-2150/2018.08.002
This study addresses the fundamental principle of inter-synaptic
interactions in synaptic cross-talk through homosynaptic and heterosynaptic
plasticity by studying the intrinsic calcium signaling dynamics in spines.
Beyond the calcium influx into synapse through voltage gated calcium channels
(VGCCs) and N-methyl-D-aspartate (NNMDA) receptors, the function of calcium
released from internal store in mediating inter-synaptic cross-talk has barely
been modeled. This work investigates how different sources of calcium
contribute to inter-synaptic cross-talk and synaptic clustering. Based on
experimental observations, we developed a mathematical model in one dimensional system
with uniform distribution of spines with the connected dendrite. We modeled the
biophysical process of calcium induced calcium release (CICR) in the dendritic
smooth endoplasmic reticulum (SER). Our model compared distinct roles of
calcium diffusion, back propagated action potentials (bAPs) and CICR played in
synaptic clustering and inter-synaptic cross-talk. The simulation result
demonstrated that calcium signal extruded from spine into dendrite requires
amplification by CICR before invading neighboring spines to induce plasticity. Our model predicted that initial calcium concentration in SER may discriminate
between different types of neuronal activity and induce completely different
synaptic potentiation and depression.
Heterosynaptic plasticity, calcium dynamics, back propagated action potentials, CICR, diffusion, long-term potentiation (LTP), long-term depression (LTD).
Zhong, Z., and Li, Y. 2018. “How Spines Cross-Talk: Compartmental Model of Heterosynaptic Plasticity.” Journal of Pharmacy and Pharmacology 6 (8): 712-728.