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Article
Author(s)
Vanessa Bagnarello-Madrigal2, Daniela Rodríguez-Chaves1, Javier Alpizar-Cordero1, Alonso Calvo-Vargas1, Maribel Cordero-Villalobos1, Misael Chinchilla-Carmona2, Idalia Valerio-Campos2 and Ronald Sánchez -Porras3
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DOI:10.17265/1934-7391/2018.03.003
Affiliation(s)
1. Departamento de Química, Universidad de Ciencias Médicas (UCIMED), San José 10108, Costa Rica
2. Departamento de Investigación Básica, Universidad de Ciencias Médicas (UCIMED), San José 10108, Costa Rica
3. Sección de Biología, Sede Occidente, Universidad de Costa Rica, San José 10108, Costa Rica
ABSTRACT
Despite the breadth of knowledge about malaria, its transmission,
preventive measures and available treatments and its difficulty in controlling
the vector and the rapid spread of resistance to current drugs, there is a
stimulus to develop new research looking for active molecules. The
phytochemical studies of the active extract confirmed the presence of
alkaloids, flavonoids, coumarins, tannins, reducing compounds, anthocyanins,
terpenes, triterpenes and steroids. In the present work, it was possible to isolate
a mixture of isoquinolinic alkaloids from the tender leaves of Nectandra membranacea (Laureaceae) with
antimalarial activity. The mixture composed of (-) - gliazovine and (+) - aplogliazovine showed an IC50 value of 32.18 μg/mL against
the P. berghei NK65 strain. It is important to
continue with these studies and their chemical components isolated from N.
membranacea that could be used as an alternative the treatment of malaria.
KEYWORDS
Malaria, Nectandra membranacea, alkaloids, phytochemical screening, Laureaceae.
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