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Article
Affiliation(s)

1. Department of Chemical Sciences, Godfrey Okoye University, P. M. B 01014, Thinkers Corner, Enugu Nigeria
2. Department of Biotechnology, Federal University, Ndufu-Alike Ikwo (FUNAI), P. M. B. 1010, Abakaliki, Nigeria
3. Department of Biotechnology, Godfrey Okoye University, P. M. B 01014, Thinkers Corner, Enugu Nigeria
4. Department of Microbiology, Godfrey Okoye University, P. M. B 01014, Thinkers Corner, Enugu Nigeria
5. Department of Computer Science and Mathematics, Godfrey Okoye University, P. M. B 01014, Thinkers Corner, Enugu Nigeria
6. Department of Biochemistry, Ebonyi State University, P. M. B 53, Abakaliki, Nigeria
7. Department of Biotechnology, Ebonyi State University, P. M. B 53, Abakaliki, Nigeria

ABSTRACT

Obesity is known to be a major risk factor of type 2 diabetes (T2D) and responsible for most lipid abnormalities associated with the disease but limited data on such association are available for diabetic patients of Igbo ethnicity in the South East region of Nigeria. A case-control study involving 72 T2D patients and 75 non-diabetic (ND) patients (control) of Igbo ethnicity was conducted. Demographic and anthropometric data were obtained followed by blood collection for the determination of fasting blood sugar (FBS), total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL). Obesity based on waist circumference (WC) was significantly higher (p < 0.001) in T2D patients compared to their non-diabetic counterparts. Similarly, TC, TG and LDL levels were significantly (p < 0.001) higher in T2D patients while HDL was significantly lower (p < 0.001) in T2D patients compared to the control. The proportion of dyslipidaemia characterized by high TC, high TG, high LDL and low HDL was significantly higher (p < 0.001) in T2D patients. BMI correlated positively (p < 0.05) with WC, TC, and LDL while FBS correlated positively (p < 0.05) with TG but negatively with HDL. In conclusion, dyslipidaemia characterised by hypercholesterolaemia, hypertriglyceridaemia, elevated LDL and reduced HDL, as well as obesity were associated with T2D and correlated with FBS in this population.

KEYWORDS

Type 2 diabetes, obesity, Igbo, dyslipidaemia, Enugu.

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