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Synthesis of Urea by Ammonolysis of Propylene Carbonate
Alexander R. Elman, Igor E. Davydov and Alexander A. Stepanov
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DOI:10.17265/1934-7375/2018.01.004
Studying urea formation by ammonolysis of propylene carbonate in a liquid phase showed that this process is two-stage, and proceeds through preferred formation of 2 hydroxypropyl carbamate, besides, the rate of the first stage is much higher than the rate of the second stage (urea formation). With the aid of the HPLC and HPLC/MS methods found some other intermediate products and offered consecutive-parallel scheme of the process. The obtained results explain the composition of impurities obtained during the production of the 13C-urea for diagnostic breath tests.
Propylene carbonate ammonolysis, urea preparation, two stage process, quantitative yield of product.
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