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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Antonija Banic, Vanesa Benkovic and Aleksandar Knezevic
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DOI:10.17265/2328-2150/2018.04.004
Arterial hypertension is the leading risk mortality factor in the world according to the report by the World Health Organization. The aim of this research was to compare fixed-dose combination with free-drug combination therapy and prove that fixed-dose combination improve patient compliance and persistence, measuring blood pressure among hypertensive patients in a Croatian Adriatic city. Methods: The study included 202 patients, 101 women and 101 men, mean age 66.8 ± 9.4 with previous diagnosis of hypertension. Results: Mean blood pressure was 152.8 ± 18.8/87.3 ± 10.3 mmHg. Blood pressure control (≤ 140/90 mmHg) was achieved in 24.8% of patients, 13.9% of women and 10.9% of men. Mean blood pressure in the group with fixed-dose combination was 149.2 ± 17.9/86.2 ± 8.5 mmHg, and 156.7 ± 18.9/88.4 ± 11.8 mmHg in the group with free-drug combination therapy. Conclusions: Results suggest that blood pressure control was better in patients with fixed-dose combinations than in patients with free-drug combinations. Fixed-drug combination improved compliance and adherence in patients with antihypertensive therapy. Results of the study indicate that fixed-drug combination should be considered in patients with hypertension according to the guidelines.
Hypertension, fixed -dose combinations, compliance, adherence, Croatia.
Banic, A., et al. 2018. “Effectiveness of Hypertension Therapy by Using Fixed Combinations and Monocomponent Drugs—A Prospective Study from Croatia.” Journal of Pharmacy and Pharmacology 6 (4): 333-339.