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ABSTRACT

β-Glucans are biomacromolecules that present biological properties of medical and pharmacological interest. The chemical modification of the primary structure of these carbohydrate biopolymers is a way to enhance or achieve new biological properties. Acetylated derivatives of (1→6)-β-D-glucan (lasiodiplodan) with different degrees of substitution (0.48, 0.66, 1.03 and 1.26) were obtained and characterized by infra-red and NMR (nuclear magnetic resonance) spectroscopy, thermal analysis, X-ray diffraction and antioxidant capacity. Acetylation was confirmed by FT-IR, and 13C NMR spectroscopy. Thermal analysis indicated that unmodified lasiodiplodan and the O-acetylated β-glucan derivative of degree of substitution 0.48 presented three stages of mass-loss, whereas acetylated derivatives of DS (degree of substitution) of 0.66, 1.03 and 1.26 presented four stages of mass-loss. X-ray diffractograms demonstrated that both native and acetylated lasiodiplodan presented crystalline regions in an amorphous polymeric matrix. Scanning electron microscopy revealed that O-acetylation promoted morphologic changes in the biopolymer according to the DS. Acetylation also contributed to improve antioxidant capacity.

KEYWORDS

Exopolysaccharide, biopolymer, bioactive carbohydrate, Macromolecules.

Cite this paper

William N. Sanchez Luna., et al. 2018. “O-Acetylated (1→6)-β-D-Glucan (Lasiodiplodan): Chemical Derivatization, Characterization and Antioxidant Activity.” Journal of Pharmacy and Pharmacology 6 (4): 320-332.

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