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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Article
Occurrence of Ibuprofen in the Waters of the Bengal River in Nova Friburgo
Author(s)
Carla Mariah Oliveira Fujimaki1 and Robson Roney Bernardo2
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DOI:10.17265/2162-5263/2017.09.001
Affiliation(s)
1. Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil
2. Campus Xerem, Federal University of Rio de Janeiro, Duque de Caxias 25245-390, Brazil
ABSTRACT
The increasing use of pharmaceuticals throughout the world is generating
a new environmental problem where they are found in low concentrations, but the
long-term risks to various organisms, as well as human health, are not yet
known. These drugs, as well as their metabolites, are introduced into aquatic
environments through excretions or discharges and may cause the same exposure
as POPs (Persistent Organic Pollutants) due to its continued entry into the
environment. The aim of this work is to develop a sensitive analytical method
for the detection of ibuprofen and its metabolites in the Bengalas river that crosses the
city of Nova Friburgo in the state of Rio de Janeiro. Three collection points
were analyzed monthly in the river from its source, as well as points of
treated water throughout the city. The samples were collected monthly and
lyophilized. Subsequently, they were subjected to a solid phase extraction
(silica) with the solvent dichloromethane: hexane (1:1; v/v). The samples were evaporated over a nitrogen atmosphere and subjected to
a LC-MS (Liquid Chromatography with Mass
Spectrometry) with 5% acetic acid
gradient: acetonitrile as the mobile phase. In the search for drugs, there were
found ions and fragments of ibuprofen (m/z 206, 205, 177) that were sought and compared to with their
standard. These indicators can result in deleterious effects on aquatic life in
these bodies of water, as well as on those who use this water from the Bengalas
river.
KEYWORDS
Ibuprofen, Bengalas river, pharmaceuticals.
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