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Management of Vitamin D Insufficiency in Young Children in the Russian Federation
Irina Zakharova, Leonid Klimov, Stanislav Maltsev, Svetlana Malyavskaya, Olga Gromova, Victoria Kuryaninova, Svetlana Dolbnya, Anastasia Yagupova, Anna Kasyanova, Ekaterina Solovyeva and Ekaterina Koroleva
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DOI:10.17265/1548-6648/2017.05.002
The paper presents the results of a multicenter study assessing efficacy and safety of a course-based regimen for hypovitaminosis D management in children under the age of three years. A dose of cholecalciferol was prescribed to children differentially, based on the baseline 25(OH)D levels. The dependence of the baseline vitamin D levels on the pre-test administration of cholecalciferol has been demonstrated. A high efficacy of the proposed management regimen in children, starting from the first 6 months of life, allows to widely recommend it in outpatient clinical practice. The level of calcidiol in children following one-month administration of 1000 to 4000 IU/day increased from 23.7 ng/ml to 45.5 ng/ml (P < 0.001), and the frequency of normal levels increased from 33.3% to 74.5 % (P < 0.001). The median increase in calcidiol levels following the one-month course of 1000 IU/day, 2000 IU/day, 3000 IU/day, and 4000 IU/day was 2.9 ng/ml, 22.3 ng/ml, 22.6 ng/ml, and 32.0 ng/ml, respectively. An increase in 25(OH)D levels closely correlates with the daily dose of cholecalciferol (r = 0.504, P < 0.001). The regimen proposed by the authors demonstrated, along with the efficacy, a high safety profile, the threshold limit of 100 ng/ml being exceeded only in 3.9% of children.
Young children, hypovitaminosis D, cholecalciferol, prevention, pharmaceutical management, course dose.