Affiliation(s)
1. Department of Pediatric, FSBEI HPT “Russian Medical Academy of Postgraduate Continuing Education” of the Ministry of Health, Moscow 123995, Russia Federation
2. Department of Pediatric, FSBEI HE “Stavropol State Medical University” of the Ministry of Health, Stavropol 355002, Russia Federation
3. Department of Biochemistry and of Experimental Medicine, The Children’s Memorial Health Institute, Warsaw, Poland
ABSTRACT
School-aged children and their health conditions, in particular, deficient conditions are not less note worthy than in younger children, while the recognition of present low vitamin D provision in children of all age groups has not still resulted in implementation of mass prophylaxis of hypovitaminosis D. There are several
factors on which blood concentration of 25 (OH) D—calcidiol-depends.
However, it is evident that among numerous factors we should
orient on several most significant and develop correction scheme for the
deficient condition in every region. Aim: to assess vitamin D levels in adolescents residing in Moscow,
to correct their calcidiol status based on a baseline blood concentration of
the transport metabolite. Materials and methods: 769
adolescents aged 11-18 years were examined and their blood
concentration of 25 (OH) D was determined. Then, 218 patients
were randomized to 2 groups: the treatment
group received food supplement “Minisun® Vitamin D3” in
tablets, the control group received placebo. Cholecalciferol dosage was
prescribed depending on the baseline calcidiol level in patients. The study continued for 6 months, after that blood was
re-withdrawn for calcidiol level. Results: low calcidiol provision was observed among school children: median 25 (ОН) D was 16.3 [11.4-20.8] ng/mL, only 5.2% of
patients had normal blood concentration of calcidiol. There-examination showed
significant differences in vitamin D status in the treatment and control group,
in the meantime, during cholecalciferol supplementation, median 25 (OH) D in patients of the
treatment group was increased from 16.2 [12.25-19.3] ng/mL to 24.2 [21.05-26.4] ng/mL (p < 0.001). Conclusions: the larger part of child population—70.6% has 25 (OH) D concentration < 20 ng/mL, cholecalciferol doses used in the study allow eliminating calcidiol deficiency
and overcome the boundary of 20 ng/mL, but for normalization
of vitamin D status in blood of
adolescents residing in Moscow higher dosages shall be used which is to be
confirmed by further studies.
KEYWORDS
School-aged children,
adolescents, vitamin D provision, vitamin D insufficiency,
vitamin D deficiency,
correction of a low vitamin D status.
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