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Mojtaba Beyramzadeh, Mohammad Hassan Khadem Ansari, Kaveh Azimzadeh and Siamak Salami
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DOI:10.17265/2328-2150/2017.10.002
Objective: We aimed to investigate protective effects of vit E on oxidative stress status and homocysteine (Hcy) in cardiac tissue of diabetic rats. Methods: Sixteen Wistar male rats were treated with STZ (streptozotocin) (60 mg/kg) to induce diabetes. Diabetic rats were divided into two groups: NTD (non-treated diabetic) and VETD (vit E-treated diabetic) rats. The VETD group received 300 mg/kg vit E with daily feeding. Eight normal rats of the same age were used as the control group. After 6 weeks, the rats were anesthetized, their cardiac tissue was removed, and homogenated supernatant was separated. Samples were assayed for TAC (total antioxidant capacity), LPO (lipid peroxidation), nitrite (NO2-), nitrate (NO3-), and Hcy. Key Findings: The contents of LPO, NO3-and Hcy in NTD compared to control group indicate a significant increase, but the levels of these parameters decreased in VETD (p < 0.05). There was a significant decrease in the amount of TAC in the NTD group but in VETD group, that significantly increased (p < 0.05). The amount of NO2- in NTD and VETD groups, compared to the control group, did not show any significant changes (p > 0.05). Conclusions: Significant decrease of oxidative stress and Hcy in the cardiac tissue caused by vit E supplementation strongly indicated that this radical scavenger may promote a protective effect on diabetic cardiomyopathy through the attenuation of oxidative stress and increase antioxidant defense mechanism.
Vitamin E, oxidative stress, homocysteine, diabetic rats.
Beyramzadeh, M., et al. 2017. “Protective Effects of Vitamin E on Diabetes-induced Oxidative Stress Status and Homocysteine in the Rat Heart.” Journal of Pharmacy and Pharmacology 5 (10): 708-716.