Affiliation(s)
1. Newborn Department, Mulac Hospital, Pilsen 301 00, Czech Republic
2. Department of Clinical Chemistry and Hematology, Mulac Hospital, Pilsen 301 00 Czech Republic
3. Department of Pediatrics, Faculty of Medicine, Faculty Hospital, Charles University, Pilsen 301 00, Czech Republic
4. Department of Health Accounting and Statistics, University Hospital Pilsen 301 00, Czech Republic
ABSTRACT
We examined IgE levels in 4,312 samples of
umbilical blood taken from children born into families with a positive history
of allergy in one or both parents from 1998-2015. At the age of ten days, those
with high IgE were given Colinfant Newborn (a lyophilized non-pathogenic strain
of E. coli) for one month, three times weekly. At 15 months and
three years we investigated the levels of IgE, IgA and IgG, and the incidence
of illness and allergy. The results revealed that allergy and high umbilical
IgE is strongly linked with family history (p ≤ 0.001). We also detected
differences in seasonality, especially with regards to pollen allergies. About 80% of children treated
with Colinfant had significantly reduced IgE and morbidity at 13-15 months and
3 years, and furthermore without any clinical signs of allergy. Surprisingly 20% of treated children
did not have reduced IgE, and yet they did not have any clinical signs of
allergy. Normalization of IgA and IgG was seen in 90% of treated subjects (p ≤ 0.001). These levels significantly are correlated with an
almost negligible morbidity up to 4 years of life. Our study strongly suggests
a positive effect of physiological E. coli on the microbiome of
children as evidenced by a significantly reduced incidence of allergy and
morbidity when applied early in life.
KEYWORDS
Microbiome, allergy,
immunology, newborn, probiotics.
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