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Article
The Role of AMPK in Metabolic Changes in Pancreatic Cancer Cells through High Protein Diet
Author(s)
Kiana Khazaei
Full-Text PDF XML 795 Views
DOI:10.17265/2328-7136/2017.04.005
Affiliation(s)
Biotechnology Program, Institute of Parasitology, McGill University, Saine-Anne-de-Bellevue, Quebec H9X 3V9, Canada
ABSTRACT
The present study
investigates the contribution of
AMPK response and mTOR (mammalian target of rapamycin) pathways through high protein diet to the pancreas cancer susceptibility. The hypothalamic modulation of the AMPK/ACC and mTOR
signaling pathways induce by HPD and are followed by assaying the tumorigenicity. The results demonstrate that AMPK and mTOR cooperated
in the hypothalamus during HPD and resulted in reducing AMPK activity, and
increasing mTOR activity.
KEYWORDS
AMPK, pancreas cancer, HPD, tumor suppressor, tumor promoter.
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