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Hesperidin Reduces Cisplatin-Induced DNA Damage in Bone Marrow Cells of Mice
Tatiane da Silva Passos, Esdras Andrade Santana, Mainã Mantovanelli da Mota, Jean Carlos Vencioneck Dutra, Juliana Macedo Delarmelina and Maria do Carmo Pimentel Batitucci
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DOI:10.17265/2328-2150/2017.05.008
Hesperidin is a bioflavonoid abundantly found in citrus fruits and displays chemoprotective effects against DNA (deoxyribonucleic acid) damage, however there are few reports about hesperidin effects against cisplatin—DNA damage induction. The aim of this work was to evaluate hesperidin antimutagenicity against cisplatin—DNA damage. (1) The antimutagenicity of hesperidin was assayed by bone marrow of mice in vivo using the micronucleus test. Hesperidin pre-treatment protocol reduced the frequency of MNPCE (micronucleated polychromatic erythrocytes) and the dose of 100 mg·kg-1 was highest efficiency, with 65.24% of damage reduction. In the simultaneous treatment protocol, the dose of 200 mg·kg-1 exhibited a more effective reduction of MNPCE, with 94.01% of damage reduction. (2) Hesperidin was also effective in reducing the MNPCE frequency in the post-treatment protocol for all doses, with 77.48%, 82.13% and 90.08% of damage reduction at the doses of 100, 200 and 400 mg·kg-1, respectively. From the study, it can be concluded that hesperidin was able to promote the reduction of micronuclei frequency and DNA damage induced by cisplatin. Hesperidin is a powerful antioxidant compound and its chemoprotective effects on DNA may occur due to its association with the antioxidant cell system which is responsible for eliminate free radicals generated by chemical harmful to DNA.
Hesperidin, micronucleus test, DNA damage, chemoprotection, antimutagenicity.
da Silva Passos, Tatiane., et al. 2017. "Hesperidin Reduces Cisplatin-Induced DNA Damage in Bone Marrow Cells of Mice." Journal of Pharmacy and Pharmacology 5 (5): 282-288.