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Sixteen Years of Trastuzumab Use: Complete Response in Lung, Bone, and CNS Metastasis from Breast Cancer




Author(s)

Maria de Lourdes Lopes de Oliveira and Gabriela Passos

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DOI:10.17265/2328-2150/2017.05.006

Although metastatic breast cancer is considered as an incurable disease, various biological drivers influence the outcomes. The use of trastuzumab in patients overexpressing HER(human epidermal growth factor receptor 2)-2 increases long-term survival even in those patients who developed brain metastasis. Nevertheless, special attention must be paid to the risk of cardiotoxicity. We report the case of a young woman with HER-2-positive breast cancer with bone and lung disease who developed brain metastasis during treatment with trastuzumab. The treatment has been continued and she is alive and in complete remission after 16 years.

Trastuzumab, long-term survival, brain metastasis, complete response, breast cancer.

de Lourdes Lopes de Oliveira, M., and Passos, G. 2017. "Sixteen Years of Trastuzumab Use: Complete Response in Lung, Bone, and CNS Metastasis from Breast Cancer." Journal of Pharmacy and Pharmacology 5 (5): 270-274.