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ABSTRACT

Acute and repeat-dose toxic effects of HOC (7-hydroxycoumarin), ethanol and their mixture were studied in rats. Single oral administration of HOC (5,000 mg/kg) caused transitional glycosuria associated with lowered serum glucose levels, decreased urea clearance. HOC given orally during 28 days (200 mg/kg) decreased serum glucose, and increased serum triglyceride concentrations. No enhancement of acute toxic effect of HOC (5,000 mg/kg) and ethanol (6,000 mg/kg) mixture was found in the acute toxicity study phase. Effect of HOC (200 mg/kg) and ethanol (750 mg/kg) during 28 days of exposure was less pronounced in comparison with HOC effect only, as far as neither decrease of glucose, nor increase of triglyceride serum concentrations were found.

KEYWORDS

7-hydroxicoumarin, ethanol, mixture toxicity.

Cite this paper

Maryna L. Zinovieva and Peter G. Zhminko. 2017. “Single and Repeat Dose Toxicity Study of 7-Hydroxycoumarin, Ethanol, and Their Mixture in Rats.” Journal of Pharmacy and Pharmacology 5 (5): 237-244.

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