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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Article
Author(s)
Guenzet Akila, Krouf Djamil and Berzou Sadia
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DOI:10.17265/2328-2150/2017.03.004
Affiliation(s)
ABSTRACT
The aim of this study was
to investigate the antihyperglycemic and antioxidant effects of Po (Portulaca oleracea) lyophilised aqueous
extract in diabetic male Wistar rats. Diabetes was induced
intraperitonially by
a single injection of STZ (streptozotocin) (60
mg/kg bw (body weight)). Twenty diabetic rats, weighing 263 ± 5 g, were divided into
two groups fed a casein diet supplemented or not with Po extract (1 g/kg bw), for four weeks. Control group
(n = 6) received 0.23~0.25 mL of citrate buffer and was fed a standard diet
during the experiment. The study was carried out at Oran University, Algeria and the
entire experiments lasted from September 2011 to July 2012. Blood was obtained
from the abdominal aorta of rats after fasting overnight and standard methods
were used for the extraction of spices, determination of glycemia, insulinemia,
lipid peroxidation and antioxidant enzymes activities. Portulaca oleracea treated compared to untreated rats, glycemia and HbA1c values were respectively
2.8- and 1.7-fold lower. TBARS (thiobarbituric acid reactive substances)
concentrations were reduced in RBC (red blood cells) (−54%) and plasma (−65%). Moreover, in liver and kidney, TBARS values were
respectively 1.8- and 2-fold lower. SOD (superoxide dismutase) and GSH-Px (glutathione
peroxidase) activities were increased respectively by +38% and +85%, in liver. GSSG-Red
(glutathione reductase)
activity was 1.9-fold higher in kidney, while CAT (catalase) was improved in kidney (+48%). In RBCs, SOD,
GSH-Px, GSSH-Red and CAT activities were increased by 31%, 42%, 56% and +50%,
respectively. These data have cast
a new light on the actions of Portulaca oleracea and its antioxidant
potential benefits in preventing diabetes and its complications.
KEYWORDS
Portulaca oleracea, rats, diabetes, streptozotocin, antioxidative enzymes, TBARS.
Cite this paper
Akila, G., Djamil, K., and Sadia, B. 2017. “Portulaca oleracea Leaf Aqueous Lyophilized Extract Reduces Hyperglycemia and Improves Antioxidant Status of Red Blood Cells and Liver in Streptozotocin-Induced Diabetic Wistar Rats.” Journal of Pharmacy and Pharmacology 5 (3): 139-148.
References