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Article
Drug-Drug Interaction Studies of Levocetirizine with Atenolol
Author(s)
Shafaque Mehboob, Muhammad Azhar Mughal, Khalid Aftab, Moona Mehboob Khan, Najma Sultana and Syed Arayne
Full-Text PDF XML 618 Views
DOI:10.17265/2328-2150/2017.03.002
Affiliation(s)
ABSTRACT
The objective of the study
was to evaluate the drug-drug interaction studies of levoceterizine with atenolol. Calibration curve
studies of working standard solutions of levocetirizine and atenolol (0.01~0.1 mmol) were
scanned. Maxima appeared at 231 nm for levocetirizine
and 224 nm for atenolol. The calibration curve obeyed Beer Lambert’s Law. Lone
availabilities of both the drugs were studied in pH 1, pH 4, pH 7.4 and pH 9 at 37 °C on B.P. (British Pharmacopoeia)
dissolution apparatus. To study the drug-drug interaction of levocetirizine (5 mg tablet) and
atenolol (100 mg tablet), both the
drugs were introduced to the dissolution apparatus in simulated gastric juice
(pH 1), pH 4, pH 7.4 and pH 9 at
37 °C at zero time and
measured the absorbance
maxima of both the drugs at the corresponding wavelength. Graphs were plotted
for availability percentage (%) of drug versus time at each set of experiment. The availability percentage (%) of levocetirizine in
the buffers of pH simulated to gastric pH 4, pH 7.4 and pH 9 in the presence of
atenolol was 436.78%, 376.90%, 436.78% and 436.78%, respectively, but the availability of atenolol was increased up to
214.80%, 212.96%, 214.93% and 231.51% in simulated to gastric pH and in the
buffers of pH 4, pH 7.4
and pH 9, respectively. On the
basis of these studies, it is concluded that levocetirizine forms a charge-complex
with atenolol; therefore, co-administration of these drugs should be avoided.
KEYWORDS
Levocetirizine, atenolol, drug-drug interactions, absorbance maxima.
Cite this paper
Mehboob, S., et al. 2017. “Drug-Drug Interaction Studies of Levocetirizine with Atenolol.” Journal of Pharmacy and Pharmacology 5 (3): 118-124.
References