Contact us
 |
[email protected] |
 |
3275638434 |
 |
 |
| Paper Publishing WeChat |
Useful Links
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Article
Evaluation of Viability of Lactobacillus fermentum CECT 5716 in Gelatin and Gastroresistant Capsules
Author(s)
María Teresa Sánchez Rodríguez, Herminia Castán Urbano, Dolores Muñoz de los Ríos, Ferderico Lara-Villoslada, María Adolfina Ruiz Martínez, María Encarnación Morales Hernández and Maria José Martín
Full-Text PDF
XML 1041 Views
DOI:10.17265/2328-2150/2016.08.009
Affiliation(s)
ABSTRACT
Different studies have
attributed health benefits to Lactobacillus
fermentum CECT 5716. However, the main problem associated with probiotics
is their low resistance to environmental and technological factors. In this
sense, capsules can provide a shell protection and a
dosage form that is easy to swallow. For these reasons, the aim of this study was to evaluate the survival of Lactobacillus fermentum CECT 5716 in
gelatin and gastro-resistant capsules during a period of 12 months at RT (room
temperature) and 4 °C. The number of encapsulated cells remained
relatively constant after six months of storage, since there were no
statistically significant differences compared to the initial time (p > 0.05). Moreover, capsules are able to maintain a
therapeutic level of bacteria (109 CFU/capsule) during the total
period of storage. Gelatin capsules seem to protect worse probiotic than
gastro-resistant (HPMC (hydroxy propyl methyl cellulose)) capsules.
Furthermore, capsules stored at 4 °C show a low level of viability.
These results suggest that HPMC capsules are an optimal dosage form for L. fermentum CECT 5716 and that the recommended condition of storage is
room temperature rather than 4 °C.
KEYWORDS
Probiotics, gastro-resistant, gelatin, capsules, Lactobacillus fermentum.
Cite this paper
Rodríguez, M. T. S., et al. 2016. “Evaluation of Viability of Lactobacillus fermentum CECT 5716 in Gelatin and Gastroresistant Capsules” Journal of Pharmacy and Pharmacology 4 (8): 413-418.
References