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Biochemical Changes in Chronic Renal Failure Pre and Post Hemodialysis



Author(s)

Entedhar Rifaat Sarhat1 and Nawal Abdullah Murtadha

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DOI:10.17265/2162-5298/2016.04.003

The aim of the study was to evaluate Paraoxonase-1 (PON-1), resistin and bone mineral markers (Parathyroid Hormone (PTH), Ca⁺⁺ and P) levels as biochemical marker for patients with Chronicrenal Failure (CRF). The sample of this study consists of 100 patients and 100 apparently healthy individuals. All patients were those who were receiving Hemodialysis (HD) therapy in the dialysis unit in Kirkuk general. The levels of PON-1, Ca⁺⁺ were significantly lower in CRF patients pre HD when compared with healthy controls, and significantly increased in post HD as compared to pre HD, but still lower than normal controls. Serum P, resistin and PTH levels were significantly higher in CRF patients pre HD process when compared with healthy controls, and their levels were significantly decreased after HD as compared to pre HD, but remained higher than controls. PON-1 was negatively correlated with the resistin, Blood Urea (BU), Creatinine (Cr), PTH, but positively correlated with Ca⁺⁺. PON-1 activity was significantly decreased in CRF patients before HD and increased after HD, but remained lower than controls. PON-1 was negatively correlated with the Body Max Index (MBI), resistin, BU, Cr, PTH, but significantly and positively correlated with Ca⁺⁺.

CRF, HD, PON-1, resistin