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Antioxidant Activity and Anti-Hyperglycemic Effect of Lagenaria Siceraria Fruit Extract



Author(s)

Nguyen Kinh Luan and Nguyen Ngoc Hong

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DOI:10.17265/2159-5828/2016.01.004

Faculty of Bio-Food Technology and Environment, HCMC University of Technology, Ho Chi Minh City, Vietnam

Lagenaria siceraria (Molina) Standl., known as bottle gourd is widely available throughout Vietnam as an edible vegetable. Bottle gourd is a commonly fruit but there are little reports about its biological activities. The aim of the present study was to evaluate antioxidant activity and anti-hyperglycemic potential of ethanolic extract of bottle gourd. The ethanolic extract was tested for its antioxidant activity on chelating power, the ferric reducing/antioxidant power assay (FRAP) and the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging assay. The results showed that chelating activity was 80.02%, FRAP value was 92.84 μmol Fe2+/g and active radical scavenging which showed an IC50 was 49.50 µg/ml. The five different doses of ethanolic extract were treated by oral tolerance to mice body before oral glucose tolerance and blood glucose level was measured using glucose oxidase method. The result indicated that inhibition percentage of ethanolic extract of bottle gourd at the dose of 400 mg/kg in glucose-induced hyperglycemic mice was effectively similar to standard drug glibenclamide. The results obtained indicate that ethanolic extract from bottle gourd is the potential antioxidant and anti-hyperglycemic agent.

Lagenaria siceraria fruit, ethanolic extract, chelating power, FRAP, DPPH, anti-hyperglycemic